AZD4547
AZD4547 (ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.
| Trivial name | ABSK 091 |
| Catalog Number | S2801 |
| Molecular Formula | C26H33N5O3 |
| CAS# | 1035270-39-3 |
| Inchi | InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ |
| Inchi Key | VRQMAABPASPXMW-HDICACEKSA-N |
| SMILES | CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/azd4547.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD4547-chemical-structure-s2801.gif |