Onvansertib (NMS-P937)

Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.

Price Not Available 10mM/1mL Onvansertib (NMS-P937) Supplier Page

Trivial name	PCM-075, NMS1286937
Catalog Number	S7255
Molecular Formula	C24H27F3N8O3
CAS#	1034616-18-6
Inchi	InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31)
Inchi Key	QHLVBNKYJGBCQJ-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/nms-p937-nms1286937.html
Additional Information	https://file.selleck.cn/downloads/struct/nms-p937-chemical-structure-s7255.gif