GNF-5837
GNF-5837 is a selective, and orally bioavailable pan-TRK inhibitor for TrkA, and TrkB with IC50 of 8 nM, and 12 nM, respectively.
| Trivial name | N/A |
| Catalog Number | S7519 |
| Molecular Formula | C28H21F4N5O2 |
| CAS# | 1033769-28-6 |
| Inchi | InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12- |
| Inchi Key | YYDUWLSETXNJJT-MTJSOVHGSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)C(=CC5=CC=CN5)C(=O)N4 |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/gnf-5837.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gnf5837-chemical-structure-s7519.gif |