Ceritinib
Ceritinib is a potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays. Ceritinib (LDK378) also inhibits IGF-1R, InsR, STK22D and FLT3 with IC50 of 8 nM, 7 nM, 23 nM and 60 nM, respectively. Phase 3.
| Trivial name | LDK378 |
| Catalog Number | S7083 |
| Molecular Formula | C28H36ClN5O3S |
| CAS# | 1032900-25-6 |
| Inchi | InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) |
| Inchi Key | VERWOWGGCGHDQE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/ldk378.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LDK378-chemical-structure-s7083.gif |