Capmatinib
Capmatinib is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
| Trivial name | INC280, NVP-INC280, INCB28060 |
| Catalog Number | S2788 |
| Molecular Formula | C23H17FN6O |
| CAS# | 1029712-80-8 |
| Inchi | InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31) |
| Inchi Key | LIOLIMKSCNQPLV-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F |
| Size | 200mg |
| Supplier Page | http://www.selleckchem.com/products/incb28060.html |
| Additional Information | https://file.selleck.cn/downloads/struct/INCB28060-chemical-structure-s2788.gif |