Pexidartinib (PLX3397)
Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.
| Trivial name | N/A |
| Catalog Number | S7818 |
| Molecular Formula | C20H15ClF3N5 |
| CAS# | 1029044-16-3 |
| Inchi | InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) |
| Inchi Key | JGWRKYUXBBNENE-UHFFFAOYSA-N |
| SMILES | C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/pexidartinib-plx3397.html |
| Additional Information | https://file.selleck.cn/downloads/struct/plx3397-chemical-structure-s7818.gif |