Lomibuvir (VX-222)
Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.
Trivial name | VCH-222 |
Catalog Number | S1480 |
Molecular Formula | C25H35NO4S |
CAS# | 1026785-59-0 |
Inchi | InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)/t16-,17-,18-,19+ |
Inchi Key | WPMJNLCLKAKMLA-UGLKCIBTSA-N |
SMILES | CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/VX-222.html |
Additional Information | https://file.selleck.cn/downloads/struct/VX-222-chemical-structure-s1408.gif |