Lomibuvir (VX-222)
Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.
| Trivial name | VCH-222 |
| Catalog Number | S1480 |
| Molecular Formula | C28H22N4O6 |
| CAS# | 1026785-59-0 |
| Inchi | InChI=1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1 |
| Inchi Key | KNJDBYZZKAZQNG-UHFFFAOYSA-N |
| SMILES | C[N+]1=C2C=CC=CC2=C(C3=CC=CC=C31)C4=C5C=CC=CC5=[N+](C6=CC=CC=C64)C.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/VX-222.html |
| Additional Information | https://file.selleck.cn/downloads/struct/VX-222-chemical-structure-s1408.gif |