BMS-777607
BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.
| Trivial name | BMS 817378 |
| Catalog Number | S1561 |
| Molecular Formula | C25H19ClF2N4O4 |
| CAS# | 1025720-94-8 |
| Inchi | InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) |
| Inchi Key | VNBRGSXVFBYQNN-UHFFFAOYSA-N |
| SMILES | CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/BMS-777607.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BMS777607-chemical-structure-S1561.gif |