Fostamatinib (R788) disodium
Fostamatinib disodium (R788, Tamatinib Fosdium), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
Trivial name | Tamatinib Fosdium |
Catalog Number | S2206 |
Molecular Formula | C28H41N7O4 |
CAS# | 1025687-58-4 |
Inchi | InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31 ,32)(H2,30,33,38)/t21-,22-,23-,26-/m1/s1 |
Inchi Key | WXRGFPHDRFQODR-ICLZECGLSA-N |
SMILES | CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O |
Size | 50mg |
Supplier Page | http://www.selleckchem.com/products/R788(Fostamatinib-disodium).html |
Additional Information | https://file.selleck.cn/downloads/struct/R935788-Fostamatinib-chemical-structure-s2206.gif |