SGI-1776 free base
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.
| Trivial name | N/A |
| Catalog Number | S2198 |
| Molecular Formula | C19 H18 Cl N5 O2 S |
| CAS# | 1025065-69-3 |
| Inchi | InChI=1S/C19H18ClN5O2S/c20-13-7-11-9-27-8-10-3-1-4-12(15(10)11)16(13)17-23-18(22)25-19(24-17)28-6-2-5-14(21)26/h1,3-4,7H,2,5-6,8-9H2,(H2,21,26)(H2,22,23,24,25) |
| Inchi Key | VIGHQZSTZWNWFA-UHFFFAOYSA-N |
| SMILES | C1C2=C3C(=CC(=C(C3=CC=C2)C4=NC(=NC(=N4)SCCCC(=O)N)N)Cl)CO1 |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/SGI-1776.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SGI-1776-chemical-structure-S2198.gif |