SGI-1776 free base
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.
| Trivial name | N/A |
| Catalog Number | S2198 |
| Molecular Formula | C24H36N6O2 |
| CAS# | 1025065-69-3 |
| Inchi | InChI=1S/C24H36N6O2/c1-2-3-10-25-24-27-16-21(23(29-24)28-19-5-7-20(31)8-6-19)22-9-4-18(15-26-22)17-30-11-13-32-14-12-30/h4,9,15-16,19-20,31H,2-3,5-8,10-14,17H2,1H3,(H2,25,27,28,29)/t19-,20- |
| Inchi Key | HSYSSKFCQHXOBP-MXVIHJGJSA-N |
| SMILES | CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C3=NC=C(C=C3)CN4CCOCC4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/SGI-1776.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SGI-1776-chemical-structure-S2198.gif |