Regorafenib (BAY-734506) Monohydrate
Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, Kit (c-Kit), RET (c-RET), RAF-1, B-RAF and B-RAF(V600E) respectively.
| Trivial name | Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate |
| Catalog Number | S5077 |
| Molecular Formula | C21H15ClF4N4O3.H2O |
| CAS# | 1019206-88-2 |
| Inchi | InChI=1S/C21H15ClF4N4O3.H2O/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26;/h2-10H,1H3,(H,27,31)(H2,29,30,32);1H2 |
| Inchi Key | ZOPOQLDXFHBOIH-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/regorafenib-monohydrate.html |
| Additional Information | https://file.selleck.cn/downloads/struct/regorafenib-monohydrate-chemical-structure-s5077.gif |