KRAS-533
KRAS-533 is a potent agonist of KRAS that binds to the GTP/GDP-binding pocket and prevents the hydrolysis of GTP, leading to accumulation of active GTP-bound KRAS. This triggers both apoptotic and autophagic cell death pathways in cancer cells, leading to potent suppression of mutant KRAS lung cancer in vitro and in animal models.
| Catalog Number | E5910 |
| Molecular Formula | C19H30N5O10P.C4H4O4 |
| CAS# | 10161-87-2 |
| Inchi | InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6 )(H,7,8)/b;2-1+/t14-;/m1./s1 |
| Inchi Key | VCMJCVGFSROFHV-WZGZYPNHSA-N |
| SMILES | CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C(=CC(=O)O)C(=O)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/kras-533.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5910-KRAS-533-chemical-structure.png |