Gefapixant
Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors, respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough.
| Trivial name | AF-219, MK-7264, R1646,RG-1646,RO 4926219 |
| Catalog Number | S6664 |
| Molecular Formula | C14H19N5O4S |
| CAS# | 1015787-98-0 |
| Inchi | InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19) |
| Inchi Key | HLWURFKMDLAKOD-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/gefapixant.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gefapixant-chemical-structure-s6664.gif |