PF-04691502
PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.
| Trivial name | PF4691502 |
| Catalog Number | S2743 |
| Molecular Formula | C22H27N5O4 |
| CAS# | 1013101-36-4 |
| Inchi | InChI=1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)/t15-,16- |
| Inchi Key | XDLYKKIQACFMJG-WKILWMFISA-N |
| SMILES | CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pf-04691502.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-04691502-chemical-structure-s2743.gif |