HDAC, EGFR & HER2 inhibitor
HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC50 values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with IC50 values of 0.93 μM, 0.71 μM, 0.90 μM respectively.
| Catalog Number | ABH-009 |
| Alternative Name(s) | 7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide; 7-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide |
| CAS# | 1012054-55-5 |
| Inchi | InChI=1S/C22H24ClFN4O4/c1-31-19-12-18-15(11-20(19)32-9-5-3-2-4-6-21(29)28-30)22(26-13-25-18)27-14-7-8-17(24)16(23)10-14/h7-8,10-13,30H,2-6,9H2,1H3,(H,28,29)(H,25,26,27) |
| Inchi Key | RQYVKBOWLRVISJ-UHFFFAOYSA-N |
| SMILES | O=C(NO)CCCCCCOC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/hdac-egfr-amp-her2-inhibitor-item-1424.html |