MK-5108
MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.
| Trivial name | VX-689 |
| Catalog Number | S2770 |
| Molecular Formula | C22H21ClFN3O3S |
| CAS# | 1010085-13-8 |
| Inchi | InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22- |
| Inchi Key | LCVIRAZGMYMNNT-VVONHTQRSA-N |
| SMILES | C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/mk-5108-vx-689.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MK-5108-chemical-structure-s2770.gif |