Silmitasertib (CX-4945)
Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.
| Trivial name | N/A |
| Catalog Number | S2248 |
| Molecular Formula | C15H26 N2 O5 |
| CAS# | 1009820-21-6 |
| Inchi | InChI=1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1 |
| Inchi Key | SCMSYZJDIQPSDI-SRVKXCTJSA-N |
| SMILES | CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1C(O1)C(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/cx-4945-silmitasertib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CX-4945-chemical-structure-S2248.gif |