AZD8055
AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
| Trivial name | N/A |
| Catalog Number | S1555 |
| Molecular Formula | C25H31N5O4 |
| CAS# | 1009298-09-2 |
| Inchi | InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1 |
| Inchi Key | KVLFRAWTRWDEDF-IRXDYDNUSA-N |
| SMILES | CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/AZD8055.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD8055-chemical-structure-S1555.gif |