BMS-754807
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1124 |
| Molecular Formula | C23H24FN9O |
| CAS# | 1001350-96-4 |
| Inchi | InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m 0/s1 |
| Inchi Key | LQVXSNNAFNGRAH-QHCPKHFHSA-N |
| SMILES | CC1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/BMS-754807.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BMS-754807-chemical-structure-S1124.gif |