KW-2449
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2158 |
| Molecular Formula | C26H26F3N7O2 |
| CAS# | 1000669-72-6 |
| Inchi | InChI=1S/C26H26F3N7O2/c1-17-14-22(25-31-24(33-38-25)19-2-6-21(7-3-19)37-26(27,28)29)32-36(17)16-18-8-9-30-23(15-18)35-12-10-34(11-13-35)20-4-5-20/h2-3,6-9,14-15,20H,4-5,10-13,16H2,1H3 |
| Inchi Key | CDJNNOJINJAXPV-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN1CC2=CC(=NC=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(C=C6)OC(F)(F)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/KW-2449.html |
| Additional Information | https://file.selleck.cn/downloads/struct/KW-2449-chemical-structure-S2158.gif |