INT-767
INT-767 is a dual agonist of farnesoid X receptor (FXR)/TGR5 with an EC50 of 0.033 μM and 0.67 μM, respectively. It significantly improves serum liver enzymes, hepatic inflammation, and biliary fibrosis, while inducing bile flow and biliary HCO₃⁻ output, making it a promising tool for chronic cholangiopathy research.
| Catalog Number | E5874 |
| Molecular Formula | C24H18F3N3O4 |
| CAS# | 1000403-03-1 |
| Inchi | InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31) |
| Inchi Key | LFKQSJNCVRGFCC-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/int-767.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5874-INT-767-chemical-structure.png |