INT-767
INT-767 is a dual agonist of farnesoid X receptor (FXR)/TGR5 with an EC50 of 0.033 μM and 0.67 μM, respectively. It significantly improves serum liver enzymes, hepatic inflammation, and biliary fibrosis, while inducing bile flow and biliary HCO₃⁻ output, making it a promising tool for chronic cholangiopathy research.
| Catalog Number | E5874 |
| Molecular Formula | C27H41NO6S |
| CAS# | 1000403-03-1 |
| Inchi | InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,2 2-,24-,27+/m0/s1 |
| Inchi Key | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
| SMILES | CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/int-767.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5874-INT-767-chemical-structure.png |