INT-767
INT-767 is a dual agonist of farnesoid X receptor (FXR)/TGR5 with an EC50 of 0.033 μM and 0.67 μM, respectively. It significantly improves serum liver enzymes, hepatic inflammation, and biliary fibrosis, while inducing bile flow and biliary HCO₃⁻ output, making it a promising tool for chronic cholangiopathy research.
| Catalog Number | E5874 |
| Molecular Formula | C17H19FN4O5S |
| CAS# | 1000403-03-1 |
| Inchi | InChI=1S/C17H19FN4O5S/c1-21-16(25)14(23)13(15(24)19-10-11-4-6-12(18)7-5-11)20-17(21)22-8-2-3-9-28(22,26)27/h4-7,23H,2-3,8-10H2,1H3,(H,19,24) |
| Inchi Key | VNIWZCGZPBJWBI-UHFFFAOYSA-N |
| SMILES | CN1C(=O)C(=C(N=C1N2CCCCS2(=O)=O)C(=O)NCC3=CC=C(C=C3)F)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/int-767.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5874-INT-767-chemical-structure.png |