Selleck Chemicals supplies over 3,000 inhibitors used in the study of cell signaling pathways. We actively tracks the latest science so our customers can rely on us to be the leading supplier of the newest inhibitors.
Company WebsiteDCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
More Information Supplier PageDCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
More Information Supplier PagedCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP by hijacking the E3 ubiquitin ligase CRBN, also is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression.
More Information Supplier PagedCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP by hijacking the E3 ubiquitin ligase CRBN, also is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression.
More Information Supplier PagedCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP by hijacking the E3 ubiquitin ligase CRBN, also is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression.
More Information Supplier PagedCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells.
More Information Supplier PagedCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells.
More Information Supplier PagedCeMM1 is a degrader of RBM39. dCeMM1 functions by altering the activity of the CRL4DCAF15 ligase, and also decreases RBM39 expression levels in wild-type KBM7 cells.
More Information Supplier PageDCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively.
More Information Supplier PageDCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively.
More Information Supplier PageDCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. DCPIB is also a novel selective blocker […]
More Information Supplier PageDDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
More Information Supplier PageDDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
More Information Supplier PageDDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.
More Information Supplier PageDDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.
More Information Supplier PageDeacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice.
More Information Supplier PageDeacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice.
More Information Supplier PageWEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.
More Information Supplier PageWEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.
More Information Supplier PageWEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.
More Information Supplier PageWEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.
More Information Supplier PageDecamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.
More Information Supplier PageDecamethylcyclopentasiloxane(Cyclomethicone 5) is an organosilicon compound. It is used in cosmetic and personal products as a skin emollient.
More Information Supplier PageDecamethylcyclopentasiloxane(Cyclomethicone 5) is an organosilicon compound. It is used in cosmetic and personal products as a skin emollient.
More Information Supplier PageDecernotinib (VX-509) is a potent and selective JAK3 inhibitor with Ki of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3.
More Information Supplier PageDecernotinib (VX-509) is a potent and selective JAK3 inhibitor with Ki of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3.
More Information Supplier PageDecitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
More Information Supplier PageDecitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
More Information Supplier PageDecitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
More Information Supplier PageDecitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
More Information Supplier PageDecitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
More Information Supplier PageDectrekumab (anti-IL-13) is a humanized monoclonal antibody that targets interleukin-13 (IL-13). It has the potential to be used in inflammation and immunology-related research. MW: 146.16 KD.
More Information Supplier PageDectrekumab (anti-IL-13) is a humanized monoclonal antibody that targets interleukin-13 (IL-13). It has the potential to be used in inflammation and immunology-related research. MW: 146.16 KD.
More Information Supplier PageDectrekumab (anti-IL-13) is a humanized monoclonal antibody that targets interleukin-13 (IL-13). It has the potential to be used in inflammation and immunology-related research. MW: 146.16 KD.
More Information Supplier PageDecumbent Bugle Herb Extract is extracted from Ajuga ciliata Bunge., has antioxidant properties.
More Information Supplier PageDecursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
More Information Supplier PageDecursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
More Information Supplier PageDecursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
More Information Supplier PageDecursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
More Information Supplier PageDecursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
More Information Supplier PageDecursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
More Information Supplier PageDecyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring.
More Information Supplier PageDeer Antler Velvet Extract is extracted from deer antler velvet, which helps in stimulating the growth of skin and hair cells.
More Information Supplier PageDEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.
More Information Supplier PageDEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
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