Abemaciclib is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.

An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.

Abiraterone is a 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer. It has a role as an antineoplastic agent and an EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor. It is a 3beta-sterol, a member of pyridines and a 3beta-hydroxy-Delta(5)-steroid. […]

Ac-rC Phosphoramidite is a commonly used protected 2-OTBDMS phosphoramidite for incorporating cytidine nucleotides into synthetic oligonucleotides.

5′-O-DMT-N4-Acetyl-2′-deoxycytidine 3′-CE phosphoramidite, a pivotal compound in the field of biomedical research, holds immense significance. Its multifarious applications transcend diverse medical domains and contribute to the advancement of disease therapeutics.

N(4)-acetylcytidine is cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group. It has a role as a metabolite. It is a member of cytidines, a member of acetamides and a secondary carboxamide.

Ac-rC Phosphoramidite is a commonly used protected 2-OTBDMS phosphoramidite for incorporating cytidine nucleotides into synthetic oligonucleotides.

Commonly used protected 2-OTBDMS phosphoramidite for incorporation of nucleotide-G into the synthesis of oligonucleotides.

5,7-dihydroxy-4′-methoxyflavone is a monomethoxyflavone that is the 4′-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is functionally related to an apigenin. It is a conjugate acid of a 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate.

Acarbose is an alpha glucosidase inhibitor which decreases intestinal absorption of carbohydrates and is used as an adjunctive therapy in the management of type 2 diabetes. Acarbose has been linked to rare instances of clinically apparent acute liver injury.

It has a role as a xenobiotic, an environmental contaminant and a sweetening agent. It is a sulfamate ester, an organonitrogen heterocyclic compound, an oxacycle and an organic heteromonocyclic compound.

antihypertensive

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug.

It has a role as an analgesic. It is a member of acetamides and an anilide.

Used to make other chemicals, as a food additive, and in petroleum production.

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.

Widely used as solvents for API synthesis and purification, solubilization of oral, topical and injectable liquid formulations, and spray drying processes.

Diethyl 1,3-acetonedicarboxylate (CAS# 105-50-0) is a reactant used in the synthesis of 2-(3-benzoylthioureido)-thiophene-3-carbonitrile derivatives with antimicrobial activity.

Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.

Peracetyl Empagliflozin is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment.

N-acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. It has a role as an antiinfective agent, an antioxidant, an antiviral drug, an antidote to paracetamol poisoning, a vulnerary, a mucolytic, a human metabolite, a radical scavenger, a ferroptosis inhibitor and a geroprotector.

A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.

Aconitine is a plant toxin found in species of wolfsbane (Aconitum genus). It is a neurotoxin previously used as an antipyretic and analgesic, and still has some limited application in herbal medicine. (L1235). The toxic effects of Aconitine have been tested in a variety of different test animals, including mammals (dog, cat, guinea pig, mouse, […]

Acotiamide monohydrochloride trihydrate is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia. Acotiamide monohydrochloride trihydrate enhances acetylcholine released by enteric neurons through muscarinic receptor antagonism and acetylcholinesterase (AChE) inhibition, thereby enhancing gastric emptying and gastric accommodation.

Acrolein is used as a chemical intermediate in many industrial synthetic processes, including in the production of acrylic acid and allyl alcohol.

Acrolein diethyl acetal is a reagent used for the synthesis of a variety of compounds, including cinnamaldehydes.

Acteoside is a glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. It is a […]

Acyclovir is an antiviral compound that can be used to induce apoptosis.

Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery.

Adefovir dipivoxil is an antiviral acyclic nucleoside phosphonate (ANP) analog.

Ademethionine 1,4-Butanedisulfonate is used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.

Adenosine is a ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond. It has a role as an anti-arrhythmia drug, a vasodilator agent, an analgesic, a human metabolite and a fundamental metabolite. It is a purines D-ribonucleoside and a member of adenosines. It is functionally related to an […]

It is used to make plastics and foams and for other uses.

Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim’s brand name Gilotrif.

A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER.

Afoxolaner is a potent isoxazoline insecticide and acaricide against Ixodes scapularis in dogs. It is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations in dogs and puppies. It is administered orally in meat-flavoured tablets, and poisons fleas once they start feeding. It is used either alone […]

Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.