OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. It binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.

A potent inhibitor of mammalian histone deacetylases (HDACs) (IC50 = 15.7 nM). A novel antitumor agent; oxamflatin modifies epigenetic status and gene expression, increases blastocyst quality, and subsequently enhances the nuclear reprogramming and developmental potential of SCNT (somatic cell nuclear transfer) embryos.

A potent PI3K/Akt/mTOR inhibitor that inhibits the TORC1 and TORC2 complexes. Displays inhibition of both Akt signaling and mTOR signaling similarly in tumor and vasculature. P529 inhibits tumor growth, angiogenesis and vascular permeability.

Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8 nM.

PCI 34051 is a potent histone deacetylase 8 (HDAC8) inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively).

A potent and selective FGFR1 tyrosine kinase inhibitor (IC50 = 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential.

A potent, selective and cell-permeable inhibitor of MAP kinase kinase (MEK). It inhibits phosphorylation of MAP kinase by MEK. PD 98059 does not inhibit MAP kinase itself.

A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.

A highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with an in vitro IC50 of 1-1.3 nM. It does not inhibit other kinases. Highly recommended tool to inhibit MKK1 or MKK1 plus MKK5.

A potent, ATP-competitive PI3K/mTOR dual inhibitor with broad antitumor activity. PF-04691502 potently inhibits recombinant class I PI3K and mTOR in biochemical assays and suppresses transformation of avian fibroblasts mediated by wild-type PI3K γ, δ, or mutant PI3Kα.

Phytofluene is a natural compound that has been found to have potential as an anticancer agent. It acts as an inhibitor of cancer cell growth and induces apoptosis, or programmed cell death, in tumor cells. Phytofluene has been shown to inhibit the activity of several important proteins involved in cancer development, including chitinase and heparin-binding […]

A natural stilbene and an analogue of Resveratrol. Besides antioxidative effects, piceatannol exhibits potential anticancer properties as shown by its ability to suppress proliferation of a wide variety of tumor cells, including leukemia, lymphoma; cancers of the breast, prostate, colon and melanoma. Also inhibits JAK-1 and Syk kinase; blocks adipogenesis of 3T3-L1 preadipocytes in a […]

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis.

A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly […]

Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum. Acts as a potent anticancer agent. Displays inhibitory effect on alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanogenesis in melanoma B16 cells (IC50= 9.6 µM). The mode of action is through the inhibition of alpha-MSH-induced tyrosinase synthesis.

Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of Ras-GAP and ERK1 with Kd values of 98 and 212 nM, respectively.

A selective inhibitor of steroyl-CoA desaturase 1 (SCD1), the key enzyme in oleic acid biosynthesis. PluriSIn 1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs (human pluripotent stem cells). Also prevents teratoma formation from tumorigenic undifferentiated cells.