L-carnitine is white crystal or white transparent fine powder, slightly special fishy smell. It is very soluble in water, ethanol, methanol, slightly soluble in acetone, insoluble in ether, benzene, trichloromethane, ethyl acetate. It is very easy to absorb moisture and will deliquesce or may even liquefy when exposed to air. It can be placed in […]

L-Ergothioneine is a natural antioxidant, which can have a protective effect on cells in the body and is an important active substance in the organism. Natural antioxidants are safe, non-toxic and have become a hot research topic. As a natural antioxidant, ergothioneine has come into people’s view, which has various physiological functions such as scavenging […]

A potent antioxidant that enhances the activity of glutathione peroxidase in endothelial cells. It induces p53-mediated cell cycle arrest and apoptosis in human colon cancer cells.

Cell-permeable. LDN193189 HCl is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 HCl functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature […]

A potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

A flavonoid compound that displays antioxidant, anti-inflammatory and anti-tumor properties. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activationAlso acts as a monoamine transporter activator.

An amide analog of Trichostatin A that potently Inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

An antioxidant chelator used in skin care. Also used in organ transplantation preservation solutions, due to its ability to inhibit hydroxyl radical production, via the complexation of oxidation-promoting iron found in blood.

Melatonin is an endogeneous hormone that plays a prominent role in the control of circadian rhythm. Melatonin acts as an agonist at melatonin receptors MT1 and MT2, displays immunomodulatory activity and acts as a powerful antioxidant that protects lipids, proteins and DNA against oxidative damage.

ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line (EC₅₀ = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC50 = 10 µM) and has no effect on 68 other targets […]

Monobenzone is a topical depigmenting agent used to treat hyperpigmentation, such as various discolorations, age spots, and melanoma, with significant effects. It can break down melanin in the skin, stop the production of melanin and restore the skin to a healthy color without destroying melanocytes. It is very mildly toxic and is usually made into […]

A useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance mechanisms. Specifically ablates zebrafish larval melanocytes or melanoblasts, and this melanocytotoxicity is dependent on tyrosinase activity.

Preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). Has no inhibitory activity towards HDAC8 (IC50>100 µM).

A potent mTOR (mammalian target of rapamycin) inhibitor (IC50 = ~10 nM for mTORC1 and mTORC2, respectively). Displays no activity against PI 3-kinase or 76 other kinases tested.

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC50 = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo.

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC50 = 0.45 nM nM). Displays 1469-fold selectivity over PI3Kα (IC50 = 661 nM).

Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC50 = 0.08 nM). Displays 75-fold selectivity over PI3Kα (IC50 = 6 nM).

Myricetin is a flavonoid compound widely found in many natural plants including bayberry. So far, myricetin has been proven to have multiple biological functions and has a therapeutic effect on many diseases, including tumors of different types, inflammatory diseases, atherosclerosis, thrombosis, cerebral ischemia, diabetes, Alzheimer’s disease and pathogenic microbial infections. Furthermore, it regulates the expression […]

N-Hexadecanoyl-alanine is a diazonium salt that is used as an intermediate in the synthesis of an acyl chain. It has been shown to inhibit the growth of cancer cells and induce apoptosis in vitro through hydrogen bonding with the fatty acid chains, which leads to membrane disruption. N-Hexadecanoyl-alanine can also react with amide groups, leading […]

N,N-Di-n-octylaniline is a chemical compound that is used as an additive in the production of polycarboxylic acids. It is also used as a monomer in the production of ester compounds. The hydroxy group on this molecule can be converted to an amide or sulfonamide group, which gives it its anti-aging properties. N,N-Di-n-octylaniline has been shown […]

Tetraethylguanidine is a carbonyl compound that contains an alkylthio group, carbonyl group, and an arylalkyl group. It is used as an additive in liquid detergents to render them resistant to hard water and as a functional group in cosmetics. Tetraethylguanidine has been shown to cross-link proteins and bind with cationic surfactants. It is also used […]

The major flavanone found in grapefruit. Acts as an antioxidant, free radical scavenger and carbohydrate metabolism promoter. Shows cytotoxicity in various human cell lines and promotes apoptosis in rat C6 glioma model. Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet. Also lowers the plasma and hepatic cholesterol concentrations […]

Cell-permeable. A promoter of neurogenesis. Neurodazine induces neuronal differentiation in skeletal muscle cells. In mouse C2C12 myoblasts, neurodazine (2 μM for seven days) upregulated the expression of neuron-specific enolase (NSE), neurofilament 200 (NF200), synapsin, and other neuronal markers. Neurodazine similarly upregulated NSE and NF200 in human skeletal muscle fibers, indicating efficacy in mature muscle as […]

Nicotinamide riboside chloride (abbreviated NR-Cl) is a precursor of an important coenzyme, also known as vitamin B3. This coenzyme is nicotinamide adenine dinucleotide (NAD+, also known as coenzyme I ), a coenzyme that transmits protons and is present in many metabolic reactions of cells. Involved in the breakdown of compounds such as proteins, carbohydrates, and […]

Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. […]

Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

A Negative control compound for the histone deacetylase (HDAC) inhibitor Scriptaid.