Ethyl (3-Hydroxyphenyl)carbamate is a carbonyl group that is produced by the hydrolysis of triticum aestivum. This product has been shown to have a synergistic interaction with retroflexus and bioassay, an imaging technique used to measure the photosynthetic activity of plants. Ethyl (3-Hydroxyphenyl)carbamate has low light fluorescence properties, which are useful for the detection of sugarbeet […]

A potent ATR (ATM and Rad3-related) inhibitor (IC50 = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC50’s of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart of stalled replication forks and abrogates S phase arrest after exposure to hydroxyurea.

Eupatorin 5-methyl ether is a flavonoid that is found in the plant Andrographis paniculata. This compound has been shown to inhibit telomerase activity and induce cell apoptosis. Eupatorin 5-methyl ether has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. The extract of this plant has […]

A derivative of the macrolide Rapamycin that acts as an immunosuppressant, mTOR inhibitor and anticancer agent. It targets the raptor mammalian target of rapamycin (mTORC1). It also inibits MERS-CoV in vitro

Fangchinoline is a bisbenzylisoquinoline alkaloid that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to inhibit cell proliferation and cell cycle progression in rat aortic vascular smooth muscle cells. Fangchinoline inhibits apoptosis of osteoblasts and protects against bone […]

A natural prodrug that inhibits Class I histone deacetylases (HDACs) (IC50 values are: 36, 47, 510 and 14000 nM for HDAC1, HDAC2, HDAC4 and HDAC6, respectively). Displays potent anticancer activities.

Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.

Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC50 = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.

A potent antitumor antibiotic . Binds specifically to heat shock protein HSP90 and its GP96 homologue; inhibits protein maturation.

An inhibitor of protein tyrosine kinase (PTK); competitive inhibitor of ATP in other protein kinase reactions.

An isoflavone glycoside found in soy-based products. Can be used as a negative control for the PTK inhibitor Genistein.

Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). in vivo, GSK2126458 displays anti-tumor activity in both pharmacodynamic and tumor growth efficacy models.

A potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC50 = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.

Gyromitrin is a potent inhibitor of tumor growth and apoptosis in human cancer cells. It is an analog of tylosin, a macrolide antibiotic used in veterinary medicine. Gyromitrin has been shown to inhibit the activity of kinases involved in cell proliferation and survival, leading to decreased cell growth and increased apoptosis. In Chinese hamster ovary […]

HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC50 values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with IC50 values of […]

Hesperetin is a naturally occurring flavonoid that displays diverse biological activities. It inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at concentrations ranging from 10 to 200 µM. Hesperetin also acts as a potent and broad-spectrum inhibitor […]

Hexadecyl (2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoate is a synthetic, nonsteroidal antiaging compound that has been shown to have cutaneous hydration effects in humans. This agent is thought to work by increasing the production of extracellular matrix proteins and by enhancing the water retention capacity of stratum corneum cells. Hexadecyl (2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoate has also been shown to improve clinical signs of […]

Cell-permeable. A potent antagonist of the Hedgehog (Hh) signaling pathway (IC50 = 70 nM).

ID-8 is a cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells in vitro. At 10 μM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. Also inhibits dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).

Cell-permeable. Directs differentiation of embryonic stem cells (ESCs) into the endodermal lineage (EC₅₀ = 125 nM). Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling pathway.

A benzoquinone analog of coenzyme Q10 that serves as a cofactor in the electron transport chain in mitochondria. Idebenone acts as a potent lipid antioxidant that prevents the generation of free radicals. Idebenone targets mitochondria, preserves mitochondrial function, and confers cytoprotection. In this way, idebenone has neuroprotective effects and has applications in Friedreich ataxia.

Intermedin B is an analytical standard that is an isolated natural product. It is a secondary metabolite that is found in plants and has been shown to have anti-inflammatory, anti-tumor, anti-viral and antioxidant activities. Intermedin B has been synthesized for use as a reference material for HPLC standards, quality control of plant derived bioactive compounds, […]

A cell-permeable indole derivative that acts as an antioxidant and mitochondrial metabolism modifier. IPAM binds to the rate-limiting component of oxidative phosphorylation in complex I of the respiratory chain and acts as a stabilizer of energy metabolism, thereby reducing the production of reactive oxygen species (ROS).

Maintains the undifferentiated state of embryonic stem cells. By targeting the PR72/130 subunit of the Ser/Thr phosphatase PP2A, it prevents β-catenin from switching coactivator usage from CBP to p300. The increase in β-cateinin/CBP mediated transcription at the expense of β-cateinin/p300-mediated transcription helps to maintain the murine stem cell pluripotency.

IR-813 is a pegylated perchlorate that is used for environmental research. IR-813 has been shown to efficiently transfer energy from the near infrared region of the electromagnetic spectrum to a fluorescent molecule. This process can be visualized using optical imaging or fluorescence microscopy. The fluorescence lifetime of IR-813 is long and it has colloidal stability […]

Isogomisin O is a plant-derived compound that has been shown to inhibit the proliferation of cells in vitro. This compound is derived from schizandra, which is a type of fruit used in traditional Chinese medicine. Isogomisin O has been shown to be effective against skin cancer and inflammatory skin diseases, as well as for anti-aging […]

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants. Displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. Acts as a soluble guanylyl cyclase activator. Also displays chemoprevention by induction of phase 2 enzymes such as quinone reductase, that protect cells against reactive, toxic, and potentially […]

Isoxanthohumol is a naturally occurring polyphenol isolated from hops that displays antioxidant, anti-inflammatory, and anti-angiogenic properties. It modulates angiogenesis and inflammation via VEGFR, TNF-α, and NF-κB pathways.

ISX9 promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory. Induces robust neuronal differentiation in adult neural stem cells. Increases insulin production by pancreatic β cells. Blocks malignant astrocyte proliferation, downregulates their astrocyte character, induces reentry into the cell cycle and upregulates neuronal gene expression.

Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and […]

Jatrorrhizine is a a novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb coptidis rhizome. Protects neuronal-like cells against H₂O₂-induced toxicity. JAT also displays neuroprotective effects against Aβ₂₅₋₃₅-induced injury via its antioxidative potential. Potential therapeutic for gastrointestinal disorders.

An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM).

A naturally occurring polyphenol antioxidant that displays a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. It reduces cell cycle progression in HT-29 cells. Kaempferol increases chromatin condensation, DNA fragmentation and the number of early apoptotic cells in HT-29 cells in a dose-dependent […]

Cell-permeable. Kartogenin promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC₅₀ = 100 nM). Displays chondroprotective effects in vitro and is efficacious in two animal models of osteoarthritis.

Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680nM) , CDK5 (IC50 = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC50 = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural […]

Promotes cardiac differentiation of human pluripotent stem cells (hPSCs) and human embryonic stem cells (hESCs) into cardiomyocytes. KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs but in a manner that is distinct from that of previously studied WNT inhibitors.

Also known as Vitamin C, Ascorbic acid functions as a powerful antioxidant, particularly in regards to reactive oxygen species (ROS). It functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Also enhances iPSC generation from both mouse and human somatic cells.