BRD-5529 is a selective, cell-permeable CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor (IC50 of 8.6 μM). BRD-5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways.

A potent small molecule anticancer agent that prevents self-renewal in Cancer Stem Cells (CSCs). Also induces cell death in CSCs and non-stem cancer cells.

Carcinine dihydrochloride is a benzyl amine derivative that is produced by the reaction of malic acid with dehydroascorbic acid. It has been shown to have activity against radiation-induced oxidative stress and is also used as an antioxidant. Carcinine dihydrochloride has been shown to inhibit epidermal growth in rats and to reduce skin tumor incidence in […]

Cell-permeable. Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes (EC50 = 100 nM).

Carnosic acid is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective and neuroprotective activities. It modulates Akt/IKK/NF-kB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells.

A potent histone deacetylase (HDAC) inhibitor (ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively). CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture (0.5-4.0 μM) and completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/ kg.

Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50 = 230 nM) and LPS-induced NF-κB activation (IC50 = 270 nM). Inhibits […]

Cell-permeable. A new benzamide class of histone deacetylase (HDAC) inhibitor with marked anti-tumor activity. It increases histone H3 acetylation levels in LoVo and HT29 colon cancer cells at concentrations as low as 4 µM. Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression […]

A potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50= 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.

Cell-permeable. A histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 µM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Displays significant antitumor activity in vitro and in vivo against a broad spectrum of murine and human tumor models.

Citicoline Sodium is a nucleic acid derivative that is an essential intermediate in the synthesis of lecithin, the main phospholipid of cell membranes. It is able to increase plasma adrenocorticotropic hormone levels as well as to intensify serum thyrotropin levels. It can also reduce cerebral vascular resistance, increase cerebral blood perfusion, and promote brain substance […]

Cleroindicin B is a reactive molecule that can be used in the treatment of diseases of aging. It was first isolated from a culture of Streptomyces cleroides, and is structurally similar to the natural amino acid lysine. Cleroindicin B has been shown to have anti-aging properties by inhibiting cellular senescence and promoting the synthesis of […]

A naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes. It is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.

Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 0.28 µM) that also targets mTOR (IC50 = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively. Fluorescence is […]

Creatine monohydrate is a pharmaceutical raw material and health product additive. It can inhibit the production of muscle fatigue factors, reduce fatigue and tension, restore physical fitness, accelerate human protein synthesis, make muscles stronger, enhance muscle elasticity, reduce cholesterol, blood lipid and blood sugar levels, improve muscle atrophy in middle-aged and elderly people, and delay […]

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved […]

Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC50 = 8 µM) and cyclooxygenase (COX) (IC50 = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and […]

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B. Cyclosporin A and its derivatives (including Alisporivir) inhibit multiple coronaviruses. Cyclosporin A and its derivatives (including Alisporivir) inhibit multiple coronaviruses.

D-chiro-inositol (DCI) is one of the nine isomers of inositol with cyclicity. In recent years, it has been found that D-chiral inositol (DCI) not only has the function of promoting hepatic lipid metabolism with inositol, but also has special physiological functions such as insulin sensitization, lowering of blood glucose, improvement of ovulation in patients with […]

Cell permeable. A potent inhibitor of γ-secretase (IC50 = 115 nM for total β-amyloid, IC50 = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances […]

Debenzoylgalloylpaeoniflorin is a poria with chemical compositions of oxypaeoniflorin, p-hydroxybenzoic acid, and malondialdehyde. It has been shown to have anti-aging effects in human dermal fibroblast cells. Debenzoylgalloylpaeoniflorin is also a bioactive compound that has been shown to inhibit the production of collagenase and other matrix metalloproteinases in vitro. This compound has also been shown to […]

An iron chelator used for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependent anemias. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Induces apoptosis in HL-60 cells by chelating iron. In addition, […]

A small-molecule inhibitor of the mammalian target of rapamycin (mTOR). Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis.

Delphinidin is a natural plant pigment. It serves as the precursor of certain anthocyanins. It is used as an anthocyanin standard.The pigment is found in grapes, cranberries, and some flowers. It is an antioxidant. It shows multiple effects. It causes vasorelaxation by inducing the release of nitric oxide by vascular endothelium. It induces apoptosis in […]

Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway.

A fungal metabolite that acts as a potent HDAC inhibitor (IC50 = 4.7 µM for HDAC1). It reverts ras- and src-transformed NIH3T3 cells to a flat phenotype (1 µg/mL).

Diethyl 2,5-Dibromoterephthalate is a donor used in solar cells. It is synthesized by reacting pyrrole with triamine to form a diethyl ester. This product is an anti-aging agent that inhibits the production of reactive oxygen species (ROS) and blocks the formation of advanced glycation end products (AGEs). Diethyl 2,5-Dibromoterephthalate has been shown to be effective […]

Dolichol-22 is a lipid molecule that functions in the biosynthesis of fatty acids. It is found in the liver cells and other tissues, where it is involved in the metabolism of cholesterol. Dolichol-22 is also an endogenous precursor of dolichyl phosphate, which is used as a cofactor for enzymes that catalyze reactions involving glycosylation. In […]

An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC50 of 5.17 µM.