Bioactive compound found in ginger (Zingiber officinale). Displays antioxidant, anti-inflammatory and antitumor properties. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages. It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Gingerol has been investigated for its effect on cancerous tumors in […]

7-(Benzyloxy)-4-oxo-4H-chromene-2-carboxamide is a reactive functional group that has an anti-aging effect. It is also a monosubstituted ether of 4-oxo-4H-chromene. The carboxylic acid group of 7-(benzyloxy)-4-oxo-4H-chromene-2 carboxamide has the ability to form polycarboxylic acid, cationic surfactants, and water vapor. This compound also possesses low energy and can act as a solvent for viruses, fatty acids, and […]

7-Fluoro-4(1H)-Quinolinone is a phenoxy compound that has been shown to have antioxidative properties. The antioxidant effect of 7-fluoro-4(1H)-quinolinone can be observed in thermally induced reactions, such as the oxidation of sulfides. It also inhibits lipid peroxidation and scavenges free radicals. 7-Fluoro-4(1H)-Quinolinone has been shown to inhibit the phospholipase A2 enzyme, which leads to decreased production […]

A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. Also recently shown to improve the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells 2-fold.

A selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs).

Acetyl-L-Carnitine Hydrochloride(Acetyl L-carnitine), an ester of L-carnitine, is a white powder, easily soluble in water and insoluble in acetone. Acetyl-L-Carnitine Hydrochloride(Acetyl L-carnitine) is a natural form of L-carnitine, which exists in the body, especially in the muscle, brain and sperm, and is involved in a series of important metabolic processes in the human body. Acetyl […]

All-trans-retinol-d5 is a supplement that is used to protect the brain from oxidative damage and to help maintain healthy skin. It is an antioxidant that prevents free radicals from damaging cells and helps maintain the structural integrity of cell membranes. All-trans-retinol-d5 can be found in high concentrations in animal tissues, such as liver, lung, kidney, […]

Allicin is a natural product isolated from garlic (Allium sativum) that exhibits many biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in lung adenocarcinoma cell lines A549 and H1299. It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases […]

Alloimperatorin is a natural product that belongs to the class of diterpenoids. It has been shown to have chemotactic and cytotoxic effects on HL-60 cells, which may be due to its ability to reduce the mitochondrial membrane potential and induce cell lysis. Alloimperatorin also has anti-inflammatory activity and inhibits collagen production in cervical cancer cells. […]

Alpha GPC powder is a natural choline compound found in the brain. It rapidly delivers choline to the brain across the blood–brain barrier. Stimulation muscle cells and all cell membranes, counteracting the age-related decrease in phospholipid (PC) biosynthesis, so it can be used as a health supplement.

Aniracetam, also known as N-anisoyl-2-pyrrolidinone, together with piracetam and nefiracetam, belongs to the same class of piracetam-metabolized drugs of brain cells. It is a non-NMDA receptor agent useful for the treatment of cognitive impairment. These drugs can enhance the activity of synaptic neurons phospholipase, increase the ATP formation and transport in the brain, increase protein […]

A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner.

A naturally occurring plant flavone that displays remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. It selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of […]

Arteannuin L is a natural product that has been shown to have anti-cancer properties. It has been shown to inhibit cancer cell growth by binding to the chloride channel and blocking the influx of ions, leading to cell death. Arteannuin L also inhibits spontaneous tumor growth in mice, which may be due to its ability […]

A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC50 of 0.8 nM. AZD8055 displays excellent selectivity (~ 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 […]

Baicalin methyl ester is a product research compound that belongs to the flavone class. It is an extract from Oroxylum indicum, which is a plant in the lamiaceae family. Baicalin methyl ester has been shown to have anti-aging properties, as well as antioxidant and anti-inflammatory effects. This compound has been used to produce liposomes and […]

NMN (Nicotinamide mononucleotide) is a naturally occurring biologically active nucleotide, known as “β-nicotinamide mononucleotide”. Since nicotinamide belongs to vitamin B3, NMN belongs to the category of vitamin B derivatives, which are widely involved in many biochemical reactions in human body and are closely related to immunity and metabolism. NMN is a nutrient that is converted […]

Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50’s at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely […]

A potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferentiated state.

Selectively impairs the G9a histone lysine methyltransferase (HMTase) and the generation of H3K9me2 in vitro. BIX-01294 enables neural progenitor cells (NPCs) to be reprogrammed in the absence of exogenous Oct4.

A fluorescent Cyclopamine derivative that retains potency in Shh signaling inhibition (IC50 = 150 nM).