PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with aDC50 value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC50 value of 0.12μM against A2780 cells. (Srtucture Note: PINK, NAMPT activator (HY-163445); Blue, VHL ligand (HY-163440); Black, linker)[1].

PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo[1], with IC50 and CC50 of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells[1].

PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor)[1].

PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity[1].

PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an […]

PROTAC SMARCA2 degrader-3 is a PROTAC degrader of the SWI/SNF ATPase subunits, SMARCA2. PROTAC SMARCA2 degrader-3 has anticancer effects (WO2023244764A1; Compound 153)[1].

PROTAC SOS1 degrader-6 (compound 23) is a potent SOS1 PROTACs degrader with synergistic efficacy with KRASG12C inhibitors[1].

PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526))[1].

PROTAC TYK2 degrader-1 (CPD-155) is a PROTAC targeting degrader to TYK2 with Dmax >60%. (Srtucture Note: PINK, TYK2 ligand 1 (HY-158340); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)

PROTAC α-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with EC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research[1].

A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity […]

Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has […]

Protein A-Cy3 is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1].

Protein A-PE is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1].

Protocatechuic acid-13C7 is 13C labeled Protocatechuic acid. Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.

Protriptyline (hydrochloride) (Standard) is the analytical standard of Protriptyline (hydrochloride). This product is intended for research and analytical applications.

PROX1 Human Pre-designed siRNA Set A contains three designed siRNAs for PROX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PROX2 Human Pre-designed siRNA Set A contains three designed siRNAs for PROX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PROZ Human Pre-designed siRNA Set A contains three designed siRNAs for PROZ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF19 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF31 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF31 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF38B Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF38B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF39 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF4 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF40A Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF40A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF40B Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF40B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF4B Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF6 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPF8 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPF8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPH Human Pre-designed siRNA Set A contains three designed siRNAs for PRPH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPH2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPS2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRPSAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRPSAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRR11 Human Pre-designed siRNA Set A contains three designed siRNAs for PRR11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRR12 Human Pre-designed siRNA Set A contains three designed siRNAs for PRR12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.