MedChem Express

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MedChemExpress has an experienced team of custom synthesis chemists, led by an impressive group of Ph.D.'s. With this team, we have the capability of supporting all kinds of chemistry projects of multiple step syntheses of complex labeled molecules, including metabolites and steroids. Following scientific and technological innovation, challenging traditional thinking, MedChemExpress has always been committed to develop quality products that exceed international standards on cost and reliability, to create the most advanced synthetic route. With high experiences in preparing a large numbers of different biologically active molecules, we provide rapid synthesis of new products. That is why we can consistently deliver your custom synthesis compounds faster than any other company.

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Exserohilone | MedChemExpress (MCE) 1 mg  | ≥98.0%

MedChem Express

Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts[1].

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Ezetimibe-d4-1 (Standard) | MedChemExpress (MCE) 1 mg  | ≥98.0%

MedChem Express

Ezetimibe-d4-1 (Standard) is the analytical standard of Ezetimibe-d4-1. This product is intended for research and analytical applications. Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

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EZH2-IN-18 | MedChemExpress (MCE) 1 mg  | ≥98.0%

MedChem Express

EZH2-IN-18 (compound 9e) is a potent inhibitor of enhancer of zeste homologue 2 (EZH2WT) with the IC50 of 1.01 nM. EZH2-IN-18 shows inhibition in proliferation and induction in apoptosis in tumor cells[1].

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EZH2/HSP90-IN-29 | MedChemExpress (MCE) 1 mg  | ≥98.0%

MedChem Express

EZH2/HSP90-IN-29 is a dual inhibitor for EZH2 and HSP90, with IC50s of 6.29 nM and 60.1 nM, for EZH2 and HSP90, respectively. EZH2/HSP90-IN-29 increases apoptosis/necrosis-related gene expression, induces cell cycle arrest at M phase and inhibits reactive oxygen species (ROS) catabolism pathway. EZH2/HSP90-IN-29 is able to cross the blood-brain-barrier (BBB)[1].

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Ezlopitant | MedChemExpress (MCE) 1 mg  | ≥98.0%

MedChem Express

Ezlopitant (CJ-11,974) is a selective, non-peptidic neurokinin-1 (NK-1)-receptor antagonist. Ezlopitant inhibits both acute and delayed emetic reactions induced by Cisplatin (HY-17394) in ferrets via acting on NK1 receptors in the central nervous system. Ezlopitant has the potential for pain, chemotherapy-induced emesis and irritable bowel syndrome research[1][2][3].

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F-Amidine TFA | MedChemExpress (MCE) 1 mg  | ≥98.0%

MedChem Express

F-Amidine TFA is a Protein arginine deiminase 4 (PAD4) inhibitor. F-Amidine TFA can be used in the study of inflammatory and immune system diseases (such as rheumatoid arthritis)[1].

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