Creative Peptides
Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.
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Nogalamycin is an anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with topoisomerase I, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
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Creative Peptides
Nogo-66 (1-40) acts as a competitive antagonist at the Nogo-66 receptor (NgR) that blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. It promotes neuron regeneration
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Creative Peptides
Nonapeptide-1 can prevent melanin synthesis and unwanted pigmentation by preventing activation of the tyrosinase, thus allowing for a better control over skin tone.
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Creative Peptides
Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree.
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Creative Peptides
Norleual is an angiotensin (Ang) IV analog, and acts as highly potent HGF/c-MET inhibitor (IC50 = 3 pM) that inhibits HGF-induced MDCK cell proliferation and invasion in vitro. It also is AT4 receptor antagonist, disrupts LTP stabilization. It shows antiangiogenic activity.
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Creative Peptides
Novexatin (NP213) is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections.
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NoxA1ds
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Creative Peptides
Cell permeable, potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM), which exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. It inhibits NOX1-derived O2- production in HT-29 human colon cancer cells, and attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
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NP-12
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Creative Peptides
NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy.
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