Creative Diagnostics
Major apple (Malus domestica) allergen Mal d 1, a ribonuclease, is a heat-sensitive allergen and belongs to the protein class of pathogenesis-related (PR) proteins. The allergen shares homologous IgE epitopes with major birch pollen allergen Bet v 1 and Cor a 1 from hazelnut pollen.
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Creative Diagnostics
Major apple (Malus domestica) allergen Mal d 1, a ribonuclease, is a heat-sensitive allergen and belongs to the protein class of pathogenesis-related (PR) proteins. The allergen shares homologous IgE epitopes with major birch pollen allergen Bet v 1 and Cor a 1 from hazelnut pollen.
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Creative Diagnostics
Mal d 3.0101, a non-specific lipid transfer protein (nsLTP), is a major apple (Malus domestica) allergen. LTPs are found mainly in aerial plant organs such as leaves, seeds, flowers, and fruit. The heat-stable protein is characterized by having resistance to pepsin hydrolysis.
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Creative Diagnostics
Pen a 1.0101, a Tropomyosin, is the only major allergen in brown shrimp Penaeus aztecus. The panallergen is a highly conserved and soluble muscle protein characterized by an alpha-helical homodimeric, coiled-coil structure.
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Creative Diagnostics
Creative Diagnostics
Creative Diagnostics
Creative Diagnostics
Creative Diagnostics
Like all profilins, minor grass pollen allergen Phl p 12.0101 is involved in cytoskeleton dynamics by binding to actin. Immunological cross-reactivity regarding IgE binding, among pollen profilins and profilins of plant-derived foods, is well known.
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Creative Diagnostics
Of 30 patients allergic to London plane tree pollen, 83% showed serum IgE binding to 43 kD protein on immunoblot of P. acerifolia extract.
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