trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[2].

trans-Nerolidol is a sesquiterpene alcohol. It can be isolated from f aerial parts of Warionia saharae ex Benth. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (HY-15142A) against intestinal cancer cells in vitro. trans-Nerolidol also has anti-fungal activity[2].

trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens.

trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function.In Vitro: trans-urocanic acid (trans-UCA) partially inhibits cytotoxic function of IL-2-activated NK cells and reduces IL-2-induced activation of NK cells. trans-urocanic acid (trans-UCA;100 μg/mL) slightly decreases cell proliferation and viability of […]

trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid.In Vitro: Two metabolic pathways for the biotransformation of trans,trans-2,4-Decadienal (tt-DDE) in vivo are proposed: (i) the oxidation of tt-DDE to the corresponding carboxylic acid, 2,4-decadienoic acid, in liver cells and (ii) glutathione (GHS) conjugation, GSH breakdown, and aldehyde reduction, which generate cysteine-conjugated 2,4-decadien-1-ol in both liver […]

Transglutaminase is an enzyme that forms crosslinks between protein molecules. Transglutaminase catalyses the formation of an isopeptide bond between the group of γ-carboxamides of glutamine residues and the first-order ε-amine groups of different compounds. Transglutaminase is involved in many physiological processes, including coagulation, antibacterial immune reactions and photosynthesis.In Vitro: Transglutaminase activity can be increased by […]

Transtorine is a quinoline alkaloid, found from Ephedra transitoria, with antibacterial activity.In Vitro:Transtorine shows growth inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa and Enterobacter cloacae, with MIC 0.38, 0.5, and 0.45 mg/mL, respectively.

Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2].IC50 & Target:IC50: 20.7 μM ( LSD1), 2.3 μM (MAO […]

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase.In Vitro: As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 […]

Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors[2].

Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin.In Vitro: In GH3 cells expressing endogenous TRH-R, Trh-gly evokes an immediate rise of intracellular calcium concentration, indicating that Trh-gly reacted directly without converting from Trh-gly to TRH[2].In Vivo: In urethane-anesthetized 2-month-old (250 g) male Sprague-Dawley rats, Trh-gly (intracisternal injection; […]

Tri-Salicylic acid is the compound with similar properties of salicylic acid. Tri-Salicylic acid has the potential for the research of inflammation, obesity and cardiovascular diseases (extracted from patent US20170368079A1, compound III).

Triacetonamine is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine is an artifact of plant and fungal extracts using acetone and ammonium hydroxide or natural occurrence of ammonium salts in various steps of the isolation procedures. TAA is the main component of the pyrolysis oil.

Triacetylresveratrol, an acetylated analog of Resveratrol. Triacetylresveratrol decreases the phosphorylation of STAT3 and NF-κB in a dose- and time- dependent manner in PANC-1 and BxPC-3 cells. Anticancer effects.In Vitro: Triacetylresveratrol significantly down-regulates anti-apoptotic Bcl-2 family protein Mcl-1 and up-regulates pro-apoptotic Bcl-2 family proteins Bim and Puma. Triacetylresveratrol inhibits cell viability, and induces apoptosis of pancreatic […]