ChemScene
rel-Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
More Information
Supplier Page
ChemScene
Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer.In Vitro:Relatlimab (BMS-986016; […]
More Information
Supplier Page
ChemScene
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment[2].IC50 & Target: IC50: 1 nM (BTK)In Vitro: In a biochemical enzyme assay,Remibrutinib (example 6) […]
More Information
Supplier Page
ChemScene
Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen has the potential for preventiong formation of a fibrotic scar or cutaneous fibrosis.In Vitro: Remlarsen (MRG-201) is active in regulating PD biomarker expression in the skin.
More Information
Supplier Page
ChemScene
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues […]
More Information
Supplier Page
ChemScene
Repaglinide D5 (AG-EE 623ZW D5) is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.In Vitro: Repaglinide reduces postprandial glucose levels by enhancing the early phase of insulin secretion and increasing the total amount of insulin secreted.
More Information
Supplier Page
ChemScene
Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride has pronounced neuroprotective effects.
More Information
Supplier Page
ChemScene
Resiquimod-d5 (R848-d5) is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α[2].
More Information
Supplier Page
ChemScene
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[2].In Vitro: Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent […]
More Information
Supplier Page
ChemScene
Resorantel is an anthelmintic. Resorantel is used in the research of paramphistomiasis in cattle and sheep and has also been used for the research of G. aegypticus[2].In Vivo: Resorantel (65 mg/kg, a single oral dose) possesses efficacy against paramphistomiasis in naturally infected sheep.
More Information
Supplier Page
