PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC[2].

PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs.In Vitro: PEG3-O-CH2COOH (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPERs that recruit inhibitor of the apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins.

PEG4-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs).

PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects.In Vitro: APG-1252 changes to the reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia.In Vivo: Pelcitoclax (APG-1252; 25-100 mg/kg; i.v.; once a day; for 10 days) treatment inhibits xenograft tumor growth more obviously than the other groups.

Pellitorine is a compound isolated from the roots of Piper nigrum. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. Pellitorine has the potential for the research of cancer diseases.

Pembrolizumab (anti-PD-1) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2].In Vivo: Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues[2].Penconazole […]

Penehyclidine (Penequinine) hydrochloride, a anticholinergic drug, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.

Penetratin is a peptide derived from the amphiphilic Drosophila Antennapedia homeodomain.

Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity.IC50 & Target:Autophagy

Pentacarboxylporphyrin I dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of […]

Pentacosane is one of the major components in the acetone extract from Curcuma raktakanda and is also in the essential oil from the leaves of Malus domestica. Pentacosane exhibit anti-cancer activities.In Vitro: Pentacosane exhibits activities against C-6, A549 (lung carcinoma), CHOK1 (ovarian), and THP-1 (acute monocytic leukemia) cells.

Pentadecyl acetate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Pentaerythritol Distearate (mixture) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Pentaerythritol-tetrakis-3-mercaptopropionate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target […]

Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.