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Imagine the power of people with a common purpose to build relationships that create value for you and your business. This is ChemScene. Every day, our people work with you to ensure you have what you need to achieve your commercial and scientific pursuits. We make sure everything we do honors that relationship starting from our commitment to ensuring that our chemicals are held to the most rigorous quality standards in the world, to the way we engage with our customers and communities to do business responsibly.

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NVS-PI3-4| ChemScene 5mg  | >98%

ChemScene

NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[2].IC50 & Target: PI3Kγ[2]In Vitro: NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2].

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NVS-ZP7-4| ChemScene 50mg  | >98%

ChemScene

NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.IC50 & Target: ZIP7.In Vitro: NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7.

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NXP800| ChemScene 5mg  | >98%

ChemScene

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has?the?potential?for?cancer research[2].In Vitro:NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM). In Vivo:NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of […]

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NY2267| ChemScene 100mg  | >98%

ChemScene

NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation.In Vitro: NY2267 strongly inhibits oncogenic transformation induced by Myc.

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Nω-Propyl-L-arginine (hydrochloride)| ChemScene 5mg  | >98%

ChemScene

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[2].In Vivo: Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2].

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