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Imagine the power of people with a common purpose to build relationships that create value for you and your business. This is ChemScene. Every day, our people work with you to ensure you have what you need to achieve your commercial and scientific pursuits. We make sure everything we do honors that relationship starting from our commitment to ensuring that our chemicals are held to the most rigorous quality standards in the world, to the way we engage with our customers and communities to do business responsibly.

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(R,R)-GSK321| ChemScene 5mg  | >98%

ChemScene

(R,R)-GSK321 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. (R,R)-GSK321 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity.IC50 & Target:IC50: 120 nM (WT IDH1)In Vitro:(R,R)-GSK321 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis.

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(R,R)-THC| ChemScene 5mg  | >98%

ChemScene

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6.

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(R)-(-)-2-Butanol| ChemScene 5g  | >98%

ChemScene

(R)-(-)-2-Butanol is released by the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol is an intermediate of pharmaceutical synthesis by coupling[2].

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(R)-(-)-α-Methylhistamine (dihydrochloride)| ChemScene 10mg  | >98%

ChemScene

(R)-(-)-α-Methylhistamine dihydrochloride is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM[2]. (R)-(-)-α-Methylhistamine dihydrochloride can enhance memory retention, attenuates memory impairment in rats.In Vitro: (R)-(-)-α-Methylhistamine dihydrochloride is an H3-agonist that is >10 times as potent as histamine (HA). Its selectivity toward H3-receptors is >1000 times as high as […]

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