Zaprinast is a cyclic-GMP phosphodiesterase inhibitor with selectivity for PDE6, 5, 11 and 9 (IC50 = 0.15, 0.76, 12.0 and 29.0 μM, respectively). C-GMP acts as a mediator of signal transduction that relaxes vascular smooth muscles and increases blood flow. Therefore zaprinast exhibits vasodilating, relaxant, and diuretic effects. Zaprinast also acts as a putative GPR35 […]

Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively.

Zarzissine isolated from the leaves of Morus alba L.

Zastaprazan is a proton pump inhibitor.

Zatebradine is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. Its IC50 value is 10 uM of 92% inhibition of the hHCN1. It reduced the activity of oriens-lacunosum moleculare interneurons in wild-type and decreased the frequency of spontaneous inhibitory currents in postsynaptic CA1 pyramidal cells. It is a specific […]

Zatebradine hydrochloride is a potent HCN channels antagonist. It could decrease the heartbeat in a reversible manner. It is a bradycardic compound that blocks hyperpolarization-activated inward current through cyclic nucleotide-gated cation channels in sinoatrial node cells. It can block voltage-gated outward K+ currents and related neuronal hyperpolarization-activated inward current channels, but exhibits little or no […]

Zatosetron has been identified as a potent, orally available, long-acting, selective 5HT3 receptor antagonist, which is potentially useful in the treatment of central nervous system disorders such as emesis induced by oncolytic drugs, migraine, dementia, anxiety, schizophrenia, and substance abuse.

Zaurategrast is an oral α4-integrin inhibitor. It significantly decreased the capacity of lymphocytes to bind vascular adhesion molecule-1 (VCAM-1) and the expression of α4-integrin on VCAM-1-binding cells.

Zavacorilant is a glucocorticoid receptor antagonist.

Zavegepant is a highly effective and selective small molecule CGRP receptor antagonist. It is the first and only CGRP receptor antagonist for intranasal administration and is currently being developed for the treatment of acute migraine.

ZB716 is a steroidal and orally bioactive selective estrogen receptor downregulator (SERD) with antiestrogenic activity. In both tamoxifen-naive and tamoxifen-resistant breast cancer cells, ZB716 dose-dependently inhibits cell proliferation and effectively degrades the hormone receptor.

ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase. It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF).

ZCZ 011 is a cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the binding of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) to CB1 and reduces neuropathic pain in the mouse with no psychoactive effects. ZCZ 011 may be beneficial for neuropathic and inflammatory pain treatment.

ZD 2079 is a β3-adrenoceptor agonist. ZD 2079 inhibits ob gene expression and circulating leptin levels in lean mice in vivo, and has the potential to treat obesity and type 2 diabetes.

ZD 7114 hydrochloride is a β3-adrenoceptor agonist.

ZD 7155 hydrochloride is a potent, selective and competitive antagonist for the angiotensin II type 1 (AT1) receptor. ZD 7155 hydrochloride displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes (IC50 = 3.8 nM). ZD 7155 hydrochloride exhibits a longer acting duration compared to the prototype AT1 antagonist, losartan.

ZD 7288 is a reported blocker of the hyperpolarization activated cation current If (HCN channel). ZD 7288 modulates the sino-atrial node function, and slows heart rate. ZD 7288 blocks Ih in central neurons.

ZD 9379 is an antagonist of glycine site on the NMDA receptor, displaying neuroprotective effects. ZD 9379 reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke.

ZD-4190, a substituted 4-anilinoquinazoline, is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, with broad-spectrum antitumor efficacy. ZD-4190 is one of a series of VEGF RTK inhibitors that may have utility in the treatment of a range of histologically diverse […]

ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) (Ki= 13±1.7 nM), suppressing adhesion of neutrophils to TNFa-activated endothelial cells. That of cancer cells with high intracellular elastase activity was also suppressed by ZD8321.

A minor component of the zearalenone complex produced by several species of fusarium. Zearalanone is an estrogen receptor agonist (EC50 = 0.11 µM).

Zearalenone is a mycotoxin produced by Fusarium. The 100 ppm acetonitrile solution of Zearalenone, a kind of natural estrogen, could be used as standard solution.

A metabolite of Zearalenone.

Zearalenone-[13C7] is a labelled version of Zearalenone.

Zeatin Riboside is useful to biological study in putative role of adenosine A3 receptor in anti-proliferative action of N6-(2-isopentyl)adenosine.

Zeaxanthin is a carotenoid xanthophyll that plays a role in the xanthophyll cycle. Zeaxanthin is a pigment that gives paprika (made from bell peppers), corn, saffron, wolfberries, and many other plants and microbes their characteristic color. It is used for eye health.Nutritional supplement in health care products.

Zebularine is a nucleoside analogue of cytidine. It is a transition state analogue inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. It can inhibit DNA methylation and tumor growth in vitro and in vivo.

Zectivimod is an immunomodulator.

Zederone isolated from the rhizomes of Curcuma zedoaria. It induces liver enlargement with scattered white foci over the organ.

Zedoalactone B is a natural product found in Curcuma aeruginosa and Curcuma phaeocaulis. Zedoalactone B is an anti-Babesial agent with an IC50 of 1.6 μg/mL against Babesia gibsoni. It inhibits NO production with an IC50 of 23.8 μM.

Zegocractin is a selective Orai1 inhibitor that prevents Ca2+ entry in acinar cells.

Zein can be used as a biopolymer in electrospinning technique.

It is a cyclic peptide antibiotic produced by the strain of Streptomyces sp. K96-0670. It has anti-Xanthomonas oryzae, Acholeplasma laidlawii, Piricularia oryzae and Staphylococcus aureus activity, but no effect on other bacteria and fungi.

Zenarestat is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract. It was developed by Fujisawa Pharmaceutical Co Ltd and was terminated in clinic phase 3 trials.