BOC Sciences
BOC Sciences
BOC Sciences
One of the isotopic labelled form of (±)-trans-Sertraline, which could probably be used as an antidepressant agent.
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(±)-U-50488 hydrochloride is a selective κ-opioid agonist with no μ-opioid antagonist effects. (±)-U-50488 hydrochloride blocks Na+ channels at high concentrations.
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BOC Sciences
BOC Sciences
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM) that blocks the loading of acetylcholine into synaptic vesicles of cholinergic nerve terminals. The inhibition by Vesamicol attenuates acetylcholine neuronal signaling without direct effecys on signaling mechanisms.
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BOC Sciences
BOC Sciences
Starting material for the synthesis of (Z)-dehydroamino acids by Wittig-Horner reaction with aldehydes; the dehydroamino acids can be stereoselectively reduced to amino acids.
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BOC Sciences
BOC Sciences
α-Bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties.
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BOC Sciences
BOC Sciences
(±)-α-Tocopherol-(trimethyl-[13C3] phenyl) is 13C isotopic labelled (±)-α-Tocopherol. (±)-α-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.
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BOC Sciences
(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays.
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11, 12-Epoxyeicosatrienoic acid is an epoxyeicosatrienoic acid (EET). Induction of CYP2C8 in native coronary artery endothelial cells by beta-naphthoflavone enhances the formation of 11, 12-epoxyeicosatrienoic acid, as well as endothelium-derived hyperpolarizing factor-mediated hyperpolarization and relaxatioocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.
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BOC Sciences
BOC Sciences
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. 2-(14,15-Epoxyeicosatrienoyl) Glycerol (2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. 2-14,15-EG is a potent mitogen for renal epithelial cells.
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(±) 5-HETE Lactone is a unique marker for 5-lipoxygenase activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 µM) from rat basophilic leukemia cells. The lactone form is several times more potent.
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Epoxide hydrolases convert the EETs into vicinal diols, with concurrent loss of much of their biological activity. (±)5(6)-DiHET is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in vitro.
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Trans-BTP Dioxolane is a PAF receptor antagonist. This compound demonstrates competitive antagonism of PAF in a rabbit washed platelet assay (Ki = 0.3 µM).
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A naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor.
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(-)-Isopulegol is found in cornmint. (-)-Isopulegol is isolated from Mentha pulegium (European pennyroyal) and other essential oil.
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(−)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans. Exhibits broad activity against Gram-positive bacteria. Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50 = 7.0 µg/ml). Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells. Activates ATP hydrolysis and induces calcium […]
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BOC Sciences
(1-((1-Methoxyethyl)amino)-1-oxopropan-2-yl)carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of related metabolites of Bupropion (B689625).
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BOC Sciences
(1-(1H-Pyrrolo[3,2-b]pyridin-6-yl)cyclopropanamine has potential to be used in the synthesis of N-substituted azaindoles as Cdc7 kinase.
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