AdipoGen Life Sciences

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AdipoGen Life Sciences develops and manufactures new products for the Life Science Research Market in the key areas of cancer, immunology, inflammation, metabolic syndrome (diabetes, obesity), stem cell biology, and neurodegeneration. The product portfolio consists of antibodies, proteins, ELISA Kits and innovative small molecules. The chemical portfolio includes, rare antibiotics, unique natural products, synthetic kinase modulators, fluorescent probes and much more.

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Neoxaline 5 mg  | >97%

AdipoGen Life Sciences

Antimitotic. Cell cycle inhibitor at the G2/M phase. Antiproliferative. Weak CNS stimulant with weak inhibitory activity on blood platelet aggregation. Mycotoxin.

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Nexturastat A 1 mg  | >98%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5.02nM). Displays high selectivity over all other HDACs (IC50=3-10µM). Suppresses cell proliferation and promotes apoptosis in B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78. Dose-dependently induces hyperacetylation of alpha-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation. Induces cell cycle arrest in G1. […]

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Nexturastat A 5 mg  | >98%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5.02nM). Displays high selectivity over all other HDACs (IC50=3-10µM). Suppresses cell proliferation and promotes apoptosis in B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78. Dose-dependently induces hyperacetylation of alpha-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation. Induces cell cycle arrest in G1. […]

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Nexturastat B 1 mg  | >98%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50=3nM). Displays high selectivity over HDAC1 (300-fold). More soluble analog of nexturastat A (Prod. No. AG-CR1-3901). Suppresses cell proliferation of B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78 at a slightly lower concentration than nexturastat A. Shown to be effective in a mouse melanoma tumor xenograft […]

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Nexturastat B 5 mg  | >98%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50=3nM). Displays high selectivity over HDAC1 (300-fold). More soluble analog of nexturastat A (Prod. No. AG-CR1-3901). Suppresses cell proliferation of B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78 at a slightly lower concentration than nexturastat A. Shown to be effective in a mouse melanoma tumor xenograft […]

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Nickamine 100 mg  | >97%

AdipoGen Life Sciences

Reagent used as a catalyst for cross-coupling reactions between alkyl halides and carbon nucleophiles. Catalyst for alkyl-alkyl Kumada coupling of secondary alkyl halides, direct alkylation of heterocyclic C-H bonds, Sonogashira coupling of nonactivated alkyl halides, Kumada-Corriu-Tamao coupling of nonactivated alkyl halides with aryl and heteroaryl nucleophiles. Reactant of pincer NN2 ligand leading to selective carbon-carbon […]

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Nickamine 500 mg  | >97%

AdipoGen Life Sciences

Reagent used as a catalyst for cross-coupling reactions between alkyl halides and carbon nucleophiles. Catalyst for alkyl-alkyl Kumada coupling of secondary alkyl halides, direct alkylation of heterocyclic C-H bonds, Sonogashira coupling of nonactivated alkyl halides, Kumada-Corriu-Tamao coupling of nonactivated alkyl halides with aryl and heteroaryl nucleophiles. Reactant of pincer NN2 ligand leading to selective carbon-carbon […]

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Niclosamide 100 mg  | >95%

AdipoGen Life Sciences

Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/beta-catenin, Notch and mTORC1. Shown to block TNF-alpha-induced IkappaBalpha phosphorylation, translocation of p65 and the expression of NF-kappaB-regulated genes and […]

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Niclosamide 1 g  | >95%

AdipoGen Life Sciences

Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/beta-catenin, Notch and mTORC1. Shown to block TNF-alpha-induced IkappaBalpha phosphorylation, translocation of p65 and the expression of NF-kappaB-regulated genes and […]

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Niclosamide . ethanolamine 25 mg  | >98%

AdipoGen Life Sciences

With slightly better solubility properties compared to Niclosamide (Prod. No. AG-CR1-3643). Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/beta-catenin, Notch and mTORC1. Shown to block TNF-alpha-induced IkappaBalpha […]

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Nigericin . sodium salt 5 mg  | >98%

AdipoGen Life Sciences

Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator

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Nigericin . sodium salt 25 mg  | >98%

AdipoGen Life Sciences

Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator

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Nile Red 1 g  | >98%

AdipoGen Life Sciences

Uncharged, hydrophobic, photostable fluorescent probe that strongly fluoresces bright red in hydrophobic (lipid-rich) environments, but is almost nonfluorescent in water. This lipophilic stain is commonly used for the detection of intracellular lipid droplets in cells such as adipocytes by fluorescence microscopy and flow cytometry. It has been shown to detect the exposure or formation of […]

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Nile Red 5 g  | >98%

AdipoGen Life Sciences

Uncharged, hydrophobic, photostable fluorescent probe that strongly fluoresces bright red in hydrophobic (lipid-rich) environments, but is almost nonfluorescent in water. This lipophilic stain is commonly used for the detection of intracellular lipid droplets in cells such as adipocytes by fluorescence microscopy and flow cytometry. It has been shown to detect the exposure or formation of […]

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NIR 4d 10 mg  | >98%

AdipoGen Life Sciences

Near-infrared (near-IR, NIR) fluorescent dye. Near-infrared (near-IR, NIR) dyes offer important advantages over traditional visible light dyes. Because cellular or tissue components produce minimal autofluorescence in the near-IR region, near-IR dyes have the potential to offer highly specific and sensitive detection in complex biological systems. Also, because light with wavelength in the near-IR region has […]

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NIR 4d 50 mg  | >98%

AdipoGen Life Sciences

Near-infrared (near-IR, NIR) fluorescent dye. Near-infrared (near-IR, NIR) dyes offer important advantages over traditional visible light dyes. Because cellular or tissue components produce minimal autofluorescence in the near-IR region, near-IR dyes have the potential to offer highly specific and sensitive detection in complex biological systems. Also, because light with wavelength in the near-IR region has […]

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NIR-797-isothiocyanate 5 mg  | >90%

AdipoGen Life Sciences

The reagent, a cyanine dye, can be used as a label for the determination of proteins with NIR-fluorescent technology. The absorption-maxima of the reagent lies in a region of low interference by other biomolecules. The isothiocyanate-moiety is used to link the reagent to proteins which can sensitively be detected. Experiments to lower the detection-limits of […]

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NIR-797-isothiocyanate 25 mg  | >90%

AdipoGen Life Sciences

The reagent, a cyanine dye, can be used as a label for the determination of proteins with NIR-fluorescent technology. The absorption-maxima of the reagent lies in a region of low interference by other biomolecules. The isothiocyanate-moiety is used to link the reagent to proteins which can sensitively be detected. Experiments to lower the detection-limits of […]

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Nitrotetrazolium blue chloride 100 mg  | >98%

AdipoGen Life Sciences

NADPH-diaphorase substrate that competitively inhibits NOS (nitric oxide synthase). Well-known scavenger of superoxide anions. Dye that is used for detection of alkaline phosphatase in combination with 5-bromo-4-chloro-3-indoxyl phosphate (BCIP). This substrate system produces an insoluble NBT diformazan end product that is blue in color and can be observed visually. When used with BCIP, it is […]

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Nitrotetrazolium blue chloride 1 g  | >98%

AdipoGen Life Sciences

NADPH-diaphorase substrate that competitively inhibits NOS (nitric oxide synthase). Well-known scavenger of superoxide anions. Dye that is used for detection of alkaline phosphatase in combination with 5-bromo-4-chloro-3-indoxyl phosphate (BCIP). This substrate system produces an insoluble NBT diformazan end product that is blue in color and can be observed visually. When used with BCIP, it is […]

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Nocardamine 1 mg  | >95%

AdipoGen Life Sciences

Antibiotic. Anti-mycobacterial. Siderophore (iron (Fe) chelating compound). Inducer of morphological changes in insect cells. Antioxidant. Anticancer compound.

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Nocardamine 5 mg  | >95%

AdipoGen Life Sciences

Antibiotic. Anti-mycobacterial. Siderophore (iron (Fe) chelating compound). Inducer of morphological changes in insect cells. Antioxidant. Anticancer compound.

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Nocodazole 5 mg  | >98%

AdipoGen Life Sciences

Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.

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Nocodazole 10 mg  | >98%

AdipoGen Life Sciences

Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.

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Nocodazole 25 mg  | >98%

AdipoGen Life Sciences

Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.

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Nocodazole 50 mg  | >98%

AdipoGen Life Sciences

Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.

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Nordihydrocapsiate 25 mg  | >95%

AdipoGen Life Sciences

Major capsaicinoid. TRPV1 and hTRPA1 agonist. Shown to activate capsaicin receptor, also called transient receptor potential vanilloid subfamily member 1 (TRPV1), but without inducing a nociceptive response. Anti-inflammatory and anticancer compound.

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Nordihydrocapsiate 100 mg  | >95%

AdipoGen Life Sciences

Major capsaicinoid. TRPV1 and hTRPA1 agonist. Shown to activate capsaicin receptor, also called transient receptor potential vanilloid subfamily member 1 (TRPV1), but without inducing a nociceptive response. Anti-inflammatory and anticancer compound.

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Novaluron 100 mg  | >98%

AdipoGen Life Sciences

Acylurea insecticide. Insect growth inhibitor. Chitin synthase inhibitor active against larvae of Coleoptera, Homoptera, Diptera and Lepidoptera. Shown to be an inhibitor of acetylcholinesterase in B-biotype Bemisia tabaci. Compound can be used as analytical reference material.

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Novaluron 500 mg  | >98%

AdipoGen Life Sciences

Acylurea insecticide. Insect growth inhibitor. Chitin synthase inhibitor active against larvae of Coleoptera, Homoptera, Diptera and Lepidoptera. Shown to be an inhibitor of acetylcholinesterase in B-biotype Bemisia tabaci. Compound can be used as analytical reference material.

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NSC697923 1 mg  | >98%

AdipoGen Life Sciences

Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.

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NSC697923 5 mg  | >98%

AdipoGen Life Sciences

Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.

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NSC697923 25 mg  | >98%

AdipoGen Life Sciences

Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kappaB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (diffuse large B cell lymphoma) cells.

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NU6102 1 mg  | >98%

AdipoGen Life Sciences

Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor. 1’000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 µM), DYRK1A (IC50 = 0.9 µM), PDK1 (IC50 = 0.8 µM) and ROCK-II (IC50 = 0.6 µM). Inhibits cell growth.

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NU6102 5 mg  | >98%

AdipoGen Life Sciences

Potent CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A3 (IC50 = 5.4 nM) inhibitor. 1’000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1.6 µM), DYRK1A (IC50 = 0.9 µM), PDK1 (IC50 = 0.8 µM) and ROCK-II (IC50 = 0.6 µM). Inhibits cell growth.

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NVP-BEZ235 5 mg  | >98%

AdipoGen Life Sciences

Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays. Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, Enhances the […]

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NVP-BEZ235 25 mg  | >98%

AdipoGen Life Sciences

Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays. Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, Enhances the […]

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O-Desmethyltramadol hydrochloride 25 mg  | >98%

AdipoGen Life Sciences

Analgesic compound. Main active metabolite of tramadol. More potent as a &micro: opioid agonist compared to tramadol. High-affinity ligand of the delta- and kappa-opioid receptors. Inactive as serotonin reuptake inhibitor. Compound can be used as analytical reference material.

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O-Desmethyltramadol hydrochloride 100 mg  | >98%

AdipoGen Life Sciences

Analgesic compound. Main active metabolite of tramadol. More potent as a &micro: opioid agonist compared to tramadol. High-affinity ligand of the delta- and kappa-opioid receptors. Inactive as serotonin reuptake inhibitor. Compound can be used as analytical reference material.

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o-Phthaldialdehyde 1 g  | >99%

AdipoGen Life Sciences

Flow cytometry measurement tool. Fluorescence probe for glutathione and glutathione disulfide levels, primary amines, peptides and biological thiols. Reacts with primary amines to produce a product that emits a highly fluorescent blue colour. Spectral data: lambdaex 334 nm; lambdaem 455 nm (Thiol Adduct). Used for the quick visualization of histamine, characterized by the appearance of […]

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o-Phthaldialdehyde 5 g  | >99%

AdipoGen Life Sciences

Flow cytometry measurement tool. Fluorescence probe for glutathione and glutathione disulfide levels, primary amines, peptides and biological thiols. Reacts with primary amines to produce a product that emits a highly fluorescent blue colour. Spectral data: lambdaex 334 nm; lambdaem 455 nm (Thiol Adduct). Used for the quick visualization of histamine, characterized by the appearance of […]

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o-Phthaldialdehyde 25 g  | >99%

AdipoGen Life Sciences

Flow cytometry measurement tool. Fluorescence probe for glutathione and glutathione disulfide levels, primary amines, peptides and biological thiols. Reacts with primary amines to produce a product that emits a highly fluorescent blue colour. Spectral data: lambdaex 334 nm; lambdaem 455 nm (Thiol Adduct). Used for the quick visualization of histamine, characterized by the appearance of […]

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OCH 250 µg  | >95%

AdipoGen Life Sciences

Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 (IL-4) secretion and weaker interferon-gamma (IFN-gamma) secretion than alpha-GalCer both in vitro […]

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OCH 1 mg  | >95%

AdipoGen Life Sciences

Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 (IL-4) secretion and weaker interferon-gamma (IFN-gamma) secretion than alpha-GalCer both in vitro […]

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