Mouse Lungkine/CXCL15, also named WECHE, is a member of the ELR motif-containing CXC chemokines. Mouse Lungkine shares 35% aa sequence identity with human ENA-78 and 31% identity with human IL-8. CXCL15 is a novel CXC chemokine that is highly expressed in the adult mouse lung. CXCL15 has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner. Lungkine protein is secreted into bronchoalveolar space and is involved in lung-specific neutrophils trafficking. Lungkine is also chemotactic for bone marrow progenitor cells and modulates hematopoietic cell differentiation.