CCL28 (CC chemokine ligand 28)，as know as mucosae-associated epithelial chemokine (MEC), is a novel CC chemokine. Among CC chemokines, CCL28 shares the most homology with CCL27/CTACK. The CCL28 gene has been mapped to the distal region of chromosome 13. CCL28 is produced by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum . The protein signals through CCR3 and CCR10, and chemotactic for resting CD4, CD8 T-cells and eosinophils.