LLC0424
YJ9069 is a potent, selective and orally bioavailable PROTAC degrader of CDK12/CDK13. It inhibits proliferation in prostate cancer cells by inducing gene-length-dependent transcriptional elongation defects, leading to DNA damage, cell-cycle arrest, and significant tumor growth suppression in vivo.
| Catalog Number | E8304 |
| Molecular Formula | C21H25NO4 |
| Inchi | InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1 |
| Inchi Key | AEQDJSLRWYMAQI-KRWDZBQOSA-N |
| SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/llc0424.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8304-llc0424-chemical-structure-tube.png |