GEM144
GEM144 is a potent and orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC11 . It exhibits potent antiproliferative activity in vitro and antitumor efficacy in vivo by inducing p53 acetylation, p21 activation, G1/S cell cycle arrest, and apoptosis.
| Trivial name | Flezurafenibum |
| Catalog Number | E8292 |
| Molecular Formula | C9H10O3 |
| CAS# | 2487526-28-1 |
| Inchi | InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3 |
| Inchi Key | DFYRUELUNQRZTB-UHFFFAOYSA-N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gem144.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8292-gem144-chemical-structure-tube.png |