dTAGV-1 TFA
dTAGV-1 TFA is a potent and selective degrader that recruits the VHL E3 ligase to selectively degrade FKBP12F36V-tagged proteins. It enables rapid degradation of oncogenic proteins such as KRASG12V and EWS/FLI, demonstrating significant antitumor efficacy both in vitro and in vivo.
| Catalog Number | E8289 |
| Molecular Formula | C20H16N2O5 |
| CAS# | 2624313-15-9 |
| Inchi | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
| Inchi Key | HAWSQZCWOQZXHI-FQEVSTJZSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/dtagv-1-tfa.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8289-dtagv-1-tfa-chemical-structure-tube.png |