Forodesine
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels.
| Trivial name | BCX-1777; Immucillin-H |
| Catalog Number | E8203 |
| Molecular Formula | C45H74O |
| CAS# | 209799-67-7 |
| Inchi | InChI=1S/C45H74O/c1-37(2)19-11-20-38(3)21-12-22-39(4)23-13-24-40(5)25-14-26-41(6)27-15-28-42(7)29-16-30-43(8)31-17-32-44(9)33-18-34-45(10)35-36-46/h19,21,23,25,27,29,31,33,35,46H,11-18,20,22,24,26,28, 30,32,34,36H2,1-10H3/b38-21+,39-23+,40-25+,41-27+,42-29+,43-31+,44-33+,45-35+ |
| Inchi Key | AFPLNGZPBSKHHQ-MEGGAXOGSA-N |
| SMILES | CC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C)C)C)C)C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/forodesine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8203-forodesine-chemical-structure-tube.png |