Quisinostat
Quisinostat(JNJ-26481585) is a potent and orally active second-generation inhibitor of pan-Histone Deacetylase (HDAC). It inhibits HDAC1, HDAC2, HDAC4, HDAC10, HDAC11 with IC50s of 0.11 nM , 0.33 nM , 0.64 nM , 0.46 nM, 0.37 nM respectively. It exhibits potent in vivo antitumor activity and potential clinical use in various solid and hematologic malignancies.
| Trivial name | JNJ-26481585 |
| Catalog Number | E8178 |
| Molecular Formula | C21H24O10 |
| CAS# | 875320-29-9 |
| Inchi | InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1 |
| Inchi Key | IOUVKUPGCMBWBT-QNDFHXLGSA-N |
| SMILES | C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/quisinostat.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E8178-Quisinostat-chemical-structure.png |